EFFECTS OF PROPOFOL ON THE OXYHEMOGLOBIN DISSOCIATION CURVE IN-VIVO AND IN-VITRO

This study assessed in vivo and in vitro the effects of propofol on th e affinity of hemoglobin for oxygen in seven ASA 1 adults. For the in vivo study, venous blood samples were withdrawn before and after preme dication, after the injection of 2.5 mg . kg-1 of propofol and after 1 5 minutes of maintenance at an infusion rate of 0.2 mg . kg-1 . min-1. For the in vitro study, propofol was added to the blood withdrawn bef ore premedication in order to obtain two samples at a concentration of 1 mug . mL-1 and 2 mug . mL-1 respectively. Propofol changed neither in vivo, nor in vitro, the P50 and the number of Hill indicating the a ngle of the slope of the dissociation curve, nor in vivo the concentra tion of 2,3-DPG.