V. Lanza et al., EFFECTS OF PROPOFOL ON THE OXYHEMOGLOBIN DISSOCIATION CURVE IN-VIVO AND IN-VITRO, Annales francaises d'anesthesie et de reanimation, 13(2), 1994, pp. 169-171
This study assessed in vivo and in vitro the effects of propofol on th
e affinity of hemoglobin for oxygen in seven ASA 1 adults. For the in
vivo study, venous blood samples were withdrawn before and after preme
dication, after the injection of 2.5 mg . kg-1 of propofol and after 1
5 minutes of maintenance at an infusion rate of 0.2 mg . kg-1 . min-1.
For the in vitro study, propofol was added to the blood withdrawn bef
ore premedication in order to obtain two samples at a concentration of
1 mug . mL-1 and 2 mug . mL-1 respectively. Propofol changed neither
in vivo, nor in vitro, the P50 and the number of Hill indicating the a
ngle of the slope of the dissociation curve, nor in vivo the concentra
tion of 2,3-DPG.