E. Pracher et al., SUCCESSFUL BONE-MARROW TRANSPLANTATION IN A BOY WITH X-LINKED LYMPHOPROLIFERATIVE SYNDROME AND ACUTE SEVERE INFECTIOUS-MONONUCLEOSIS, Bone marrow transplantation, 13(5), 1994, pp. 655-658
We report a 5.9-year-old boy with X-linked lymphoproliferative syndrom
e (XLP) who presented with acute severe infectious mononucleosis. Clin
ical symptoms rapidly improved after chemotherapy with etoposide. Allo
geneic bone marrow transplantation (BMT) was performed after condition
ing with etoposide, busulfan and cyclophosphamide. After successful he
matopoietic recovery we were able to demonstrate seroconversion from a
n impaired antibody response to Epstein-Barr virus (EBV) to a normal a
ntibody-producing state in an immunocompetent child. The only post-tra
nsplant complication was mild acute graft-versus-host disease (GVHD).
Three years after BMT, the boy is healthy and shows no signs of immuno
deficiency. This is the first report on successful allogeneic BMT in t
he severe course of acute infectious mononucleosis in a patient with X
LP. We speculate that the application of etoposide contributed to the
positive outcome in this patient.