CORRECTION OF NEUTROPENIA WITH RHUG-CSF AFTER LOSS OF RESPONSE TO RHUGM-CSF FOLLOWING AUTOLOGOUS BONE-MARROW TRANSPLANT

We describe a patient who presented with graft failure following autol ogous BMT, with an initial response of the neutrophil count to rHuGM-C SF but eventual loss of this response. Subsequently, this patient resp onded to rHuG-CSF. This could be explained by the fact that rHuG-CSF s timulates both early and late myeloid progenitor cells whereas rHuGM-C SF stimulates mainly the intermediate myeloid progenitor cells. This f inding suggests that rHuG-CSF should be investigated for the treatment of patients with graft failure following ABMT.