ADENOSINE-DEAMINASE, 5'-NUCLEOTIDASE, XANTHINE-OXIDASE, SUPEROXIDE-DISMUTASE, AND CATALASE ACTIVITIES IN GASTRIC JUICES FROM PATIENTS WITH GASTRIC-CANCER, ULCER, AND ATROPHIC GASTRITIS

Adenosine deaminase (ADA), 5'-Nucleotidase (5NT), Xanthine oxidase (XO ), Cu-Zn Superoxide dismutase (SOD) and Catalase (CAT) activities were determined in gastric juices from patients with gastric cancer, ulcer , gastritis and from healthy subjects. Enzyme activities were given as units per mi gastric juice and units per mg protein in gastric juice. ADA, 5NT and XO activities were found lower and protein concentration s were found higher in the cancer group than controls. There was howev er no significant difference between Cu-Zn SOD activities of the cance r and control groups. In all groups including control one, we could no t find catalase activities in most of the samples. On the other hand, ADA, 5NT activities and protein concentrations in the gastric juice we re lower in the gastritis group than control group. In the ulcer group , we found higher Cu-Zn SOD and XO activities and lower 5NT activity a nd protein concentrations compared with control values. In an attempt to establish statistical correlations between mean enzyme activities, pH and protein concentrations in the gastric juices of the groups, we found noticeable intra and inter-correlations, which indicated possibl e relations between DNA and free radical metabolizing enzymes.