IMMUNOTHERAPY FOR STEWART-TREVES SYNDROME - USEFULNESS OF INTRAPLEURAL ADMINISTRATION OF TUMOR-INFILTRATING LYMPHOCYTES AGAINST MASSIVE PLEURAL EFFUSION CAUSED BY METASTATIC ANGIOSARCOMA

We describe a 56-year-old woman with Stewart-Treves syndrome who had s evere dyspnea from a pleural effusion caused by metastatic angiosarcom a in the right lung. Tumorinfiltrating lymphocytes (TIL) in the pleura l effusion were cultured and expanded in vitro in the continuous prese nce of recombinant interleukin 2 with periodic stimulation by CD3 anti body. The expanded TIL were administered intrapleurally seven times at 1- to 4-week intervals in combination with intravenous infusion of re combinant interleukin 2. A panel of T-cell clones was also obtained fr om TIL. Immunotherapy dramatically improved the patient's dyspnea and pleural effusion. A CD4(+) T-cell clone and a CD8(+) T-cell clone esta blished from TIL had specific cytotoxicity to the tumor cells.