ZYGOMYCOSIS AND HIV-INFECTION

The severe immunosuppression associated with HIV infection increases s usceptibility to opportunistic fungi. We describe a primary gangrenous cutaneous infection caused by Rhizopus arrhizus in an HIV-infected in travenous narcotic user. In addition, we review nine reported cases of zygomycosis in HIV-infected patients and discuss the frequency and ou tcome of zygomycosis in HIV infection. Eight of 10 patients were intra venous drug users. Cutaneous infection occurred in four patients. Anot her case was associated with drug-induced neutropenia. With treatment, 60% of the patients recovered. HIV-induced immunosuppression rarely p redisposes to zygomycosis except in intravenous drug users or persons with other risk factors for this fungal infection.