BIOLOGICAL-ACTIVITY OF SOME COUMARINS FROM SRI-LANKAN RUTACEAE

Authors
GUNATILAKA AAL KINGSTON DGI WIJERATNE EMK BANDARA BMR HOFMANN GA JOHNSON RK
Citation
Aal. Gunatilaka et al., BIOLOGICAL-ACTIVITY OF SOME COUMARINS FROM SRI-LANKAN RUTACEAE, Journal of natural products, 57(4), 1994, pp. 518-520
Citations number
16
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
57
Issue
4
Year of publication
1994
Pages
518 - 520
Database
ISI
SICI code
0163-3864(1994)57:4<518:BOSCFS>2.0.ZU;2-4
Abstract
Twelve coumarins isolated from plants of the Rutaceae collected in Sri Lanka have been subjected to a mechanism-based anticancer bioassay em ploying DNA repair-deficient and repair-proficient yeasts. Of these, s eselin [10] and xanthyletin [11] were found to be active. Seselin also exhibited moderate cytotoxicity.