REVERSIBLE ACTIVATION OF GABA AND L-GLUTAMATE UPTAKE INTO SYNAPTOSOMES ISOLATED FROM THE RAT-BRAIN IN RESPONSE TO A SINGLE CARBACHOLINE INJECTION INTO HIPPOCAMPUS

In the present investigation the functional activity of transport syst ems mediating the GABA and L-glutamate uptake into nerve terminals of the rat brain cortex and hippocampus in response to a single carbachol ine administration to hippocampus was studied. It has been established that synaptosomes isolated from the brain cortex and hippocampus of r ats used in the experiments 24 h after a single carbacholine injection possess an increased capability of GABA and L-glutamate accumulation, and 48 h later the GABA and L-glutamate uptake begins to return to it s control level and was equal to it on seventh day after injection. (C ) 1994 Academic Press, Inc.