Ke. Berge et K. Berg, NO EFFECT OF INSERTION DELETION POLYMORPHISM AT THE ACE LOCUS ON NORMAL BLOOD-PRESSURE LEVEL OR VARIABILITY, Clinical genetics, 45(4), 1994, pp. 169-174
Angiotensin I-converting enzyme (ACE) cleaves angiotensin I to angiote
nsin II, which is the active component in the renin-angiotensin system
(RAS). We have studied an insertion/deletion polymorphism in DNA at t
he ACE locus. In three different series comprising 140, 90 and 136 unr
elated individuals we found no evidence of association between genotyp
es in this insertion/deletion (I/D) polymorphism and level of systolic
or diastolic blood pressure. In two series of 130 and 88 monozygotic
(MZ) twin pairs, respectively, there was no difference between genotyp
es in within-pair variation in systolic or diastolic blood pressure. T
hus, in these series of healthy people, neither ''level gene'' nor ''v
ariability gene'' effects of this insertion/deletion polymorphism were
observed.