MECHANISMS OF THE DEVELOPMENT OF TRAZODONE WITHDRAWAL SYMPTOMS

Authors
OTANI K TANAKA O KANEKO S ISHIDA M YASUI N FUKUSHIMA Y
Citation
K. Otani et al., MECHANISMS OF THE DEVELOPMENT OF TRAZODONE WITHDRAWAL SYMPTOMS, International clinical psychopharmacology, 9(2), 1994, pp. 131-133
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International clinical psychopharmacology → ACNP
ISSN journal
02681315
Volume
9
Issue
2
Year of publication
1994
Pages
131 - 133
Database
ISI
SICI code
0268-1315(1994)9:2<131:MOTDOT>2.0.ZU;2-8
Abstract
Three cases developed withdrawal symptoms of trazodone despite gradual discontinuation of therapeutic doses of the drug. This report suggest s that effects of trazodone and its metabolite m-chlorophenylpiperazin e on the serotonergic system, which may result in noradrenergic reboun d after discontinuation, and short half-lives of these compounds are i nvolved in the development of these symptoms. From a clinical point of view, we suggest that trazodone should be tapered off at a very slow rate.