STRUCTURAL AND CONFORMATIONAL STUDIES OF [ILE(7)] AND [LEU(7)]SURFACTINS FROM BACILLUS-SUBTILIS-NATTO

Authors
ITOKAWA H MIYASHITA T MORITA H TAKEYA K HIRANO T HOMMA M OKA K
Citation
H. Itokawa et al., STRUCTURAL AND CONFORMATIONAL STUDIES OF [ILE(7)] AND [LEU(7)]SURFACTINS FROM BACILLUS-SUBTILIS-NATTO, Chemical and Pharmaceutical Bulletin, 42(3), 1994, pp. 604-607
Citations number
28
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
3
Year of publication
1994
Pages
604 - 607
Database
ISI
SICI code
0009-2363(1994)42:3<604:SACSO[>2.0.ZU;2-D
Abstract
A novel [Ile7]surfactin (1), which showed anti-human immunodeficiency virus activity, has been isolated from Bacillus subtilis natto. Struct ural and conformational analysis of the peptide backbone of [Ile7]surf actin was conducted by a combination of various two-dimensional (2D) n uclear magnetic resonance (NMR), circular dichroism (CD) spectroscopy and simulated annealing calculations, compared with a known [Leu7]surf actin (2). Both surfactins were shown to exist in different conformati onal states in both polar and apolar solvents.