1,4,5-TRIALKYL IMIDAZOLE SYSTEM ANTIINFLAMMATORY PROPERTIES OF NEW SUBSTITUTED DERIVATIVES

In an investigation of the anti-inflammatory properties of five-member ed ring nitrogen-containing heterocyclic compounds, two series of deri vatives of imidazole were prepared by altering the sites of substituti on and by joining aliphatic chains to the nitrogen atom in the 1 posit ion of the imidazole ring. Some of them were more potent inhibitors of carragenan-induced edema than indomethacin. An electron spin resonanc e study indicated that these compounds possess anti-radical activity.