Y. Mimaki et al., NEW STEROIDAL SAPONINS FROM THE BULBS OF ALLIUM-GIGANTEUM EXHIBITING POTENT INHIBITION OF CAMP-PHOSPHODIESTERASE ACTIVITY, Chemical and Pharmaceutical Bulletin, 42(3), 1994, pp. 710-714
A new spirostanol saponin and two new furostanol saponins were isolate
d from the fresh bulbs of Allium giganteum together with several known
saponins. The structures of the new compounds were determined on the
basis of spectroscopic data, the products formed on hydrolysis and by
comparing their properties with those of known compounds. The isolated
saponins and their derivatives were evaluated for inhibitory activity
by examining their action on cAMP phosphodiesterase as a primary scre
ening test to identify new medicinal agents.