NEW STEROIDAL SAPONINS FROM THE BULBS OF ALLIUM-GIGANTEUM EXHIBITING POTENT INHIBITION OF CAMP-PHOSPHODIESTERASE ACTIVITY

Authors
MIMAKI Y NIKAIDO T MATSUMOTO K SASHIDA Y OHMOTO T
Citation
Y. Mimaki et al., NEW STEROIDAL SAPONINS FROM THE BULBS OF ALLIUM-GIGANTEUM EXHIBITING POTENT INHIBITION OF CAMP-PHOSPHODIESTERASE ACTIVITY, Chemical and Pharmaceutical Bulletin, 42(3), 1994, pp. 710-714
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
3
Year of publication
1994
Pages
710 - 714
Database
ISI
SICI code
0009-2363(1994)42:3<710:NSSFTB>2.0.ZU;2-N
Abstract
A new spirostanol saponin and two new furostanol saponins were isolate d from the fresh bulbs of Allium giganteum together with several known saponins. The structures of the new compounds were determined on the basis of spectroscopic data, the products formed on hydrolysis and by comparing their properties with those of known compounds. The isolated saponins and their derivatives were evaluated for inhibitory activity by examining their action on cAMP phosphodiesterase as a primary scre ening test to identify new medicinal agents.