ABSENCE OF ADAPTIVE DNA-REPAIR IN XERODER MA-PIGMENTOSUM CELLS

Authors
VASILEVA IM SINELSHCHIKOVA TA LVOVA GN MELIKSETOVA IA ZASUKHINA GD
Citation
Im. Vasileva et al., ABSENCE OF ADAPTIVE DNA-REPAIR IN XERODER MA-PIGMENTOSUM CELLS, Genetika, 30(4), 1994, pp. 484-487
Citations number
4
Categorie Soggetti
Genetics & Heredity
Journal title
Genetika → ACNP
ISSN journal
00166758
Volume
30
Issue
4
Year of publication
1994
Pages
484 - 487
Database
ISI
SICI code
0016-6758(1994)30:4<484:AOADIX>2.0.ZU;2-Q
Abstract
Adaptive repair is the restoration of chemically induced DNA breaks in human fibroblasts previously gamma-irradiated at low doses. The adapt ive repair in xeroderma pigmentosum (XP) cells was compared to that in normal human fibroblasts. The obtained results suggest that the repai r is inducible and error-free. Adaptive repair was not found in XP cel ls in experiments with 4-NQO. This is correlated with the presence of an excision repair defect in XP.