THE SPECTRUM OF DNA HAPLOTYPES AND BETA-T HALASSEMIA MUTATIONS IN AZERBAIJAN

Authors
TAGIEV AF SURIN VL LUKYANENKO AV KULIEVA EA MAMEDOVA TA SOLOVEV GY
Citation
Af. Tagiev et al., THE SPECTRUM OF DNA HAPLOTYPES AND BETA-T HALASSEMIA MUTATIONS IN AZERBAIJAN, Genetika, 30(4), 1994, pp. 535-538
Citations number
20
Categorie Soggetti
Genetics & Heredity
Journal title
Genetika → ACNP
ISSN journal
00166758
Volume
30
Issue
4
Year of publication
1994
Pages
535 - 538
Database
ISI
SICI code
0016-6758(1994)30:4<535:TSODHA>2.0.ZU;2-R
Abstract
Haplotyping of the beta-globin gene cluster was performed on DNA sampl es from 110 Azerbaidzhanian beta-thalassemic patients and their famili es. During this study, we found 18 different haplotypes and determined the frequency of their occurrence. Nine of these haplotypes have neve r been observed earlier in the studied population. One of the haplotyp es was found only in beta-thalassemia alleles. Several haplotypes were associated with beta-thalassemia mutations found earlier in Azerbaidz han.