A case of severe ovarian hyperstimulation syndrome (OHSS) prompted us
to review our experience of the condition, and to critically evaluate
its clinical associations and treatment. Severe OHSS complicated 1.8%
of gamete intra-Fallopian transfer (GIFT) cycles, but none of the ovul
ation induction and artificial insemination by husband (OI/AIH) cycles
. It is difficult to establish whether the higher pregnancy rate obser
ved with OHSS was attributable to pregnancy increasing the risk of OHS
S, or if it was the development of OHSS which increased the likelihood
of pregnancy. Monitoring serum oestradiol levels and ultrasonographic
evaluation of growing follicles may be helpful in identifying women a
t risk. Strategies for reducing the risk of developing severe OHSS wer
e considered.