A CASE OF CREATINE-KINASE ISOMER ANOMALY IN RELATION TO THE DIAGNOSISOF ACUTE MYOCARDIAL-INFARCTION

Creatine kinase (CK) isomers have recently been suggested to be of val ue in the diagnosis of acute myocardial infarction (AMI). The aim of t his report was to determine whether measurement of CK isomers, especia lly the MM isomer and the cardio-specific marker MB isomer, is practic al in the diagnosis of AMI. A 64-year-old female with consistently hig h values for total CK showed an electrophoretic pattern which suggeste d AMI. We ruled out all possible causes of increased CK, and its MB is omer, including IgGBB, beta-LP (lipoprotein) and mitochondrial complex es as well as myocarditis, muscular disorders, and myoglobinuria. Rega rdless of the source of the anomaly, the fact remains that CK macroano maly cases can be an obstacle in the diagnosis of AMI. CK isomers have proven to be accurate markers in AMI and valuable in doubtful cases, such as non Q-AMI. However, in light of this particular case of CK mac roanomaly, isomers are not 100% accurate (specific) in the diagnosis o f AMI.