Background: In adult patients with atopic dermatitis (AD), the presenc
e of autoantibodies such as anti-IgE and antinuclear antibodies (ANA)
has been demonstrated. The patients may have altered immune regulation
. Objective: The purpose of this study is to examine the prevalence of
ANA in AD patients with severe facial eruptions and to evaluate the d
ifferences between ANA-positive and ANA-negative AD patients. Methods:
ANA, blood eosinophil count, total serum IgE levels, specific ISE ant
ibody to Dermatophagoides pteronyssinus, disease duration, photosensit
ivity and association with respiratory allergic diseases were checked
in 89 AD patients. Results: Twenty-three (25.8%) AD patients showed po
sitive ANA at titers ranging from 1:40 to 1:640, and the incidence of
positive ANA was 12.1% in controls. Twenty-five (71.4%) of 35 AD patie
nts with positive ANA at titers ranging from 1:20 to 1:640 were female
s. Conclusion: Adult AD patients with severe facial lesions should be
examined for serum ANA. Particularly in female and photosensitive AD p
atients with severe facial lesions, serum autoantibodies have to be ca
refully investigated to differentiate from autoimmune diseases.