THE POLAROGRAPHIC-DETERMINATION OF FLUVOXAMINE MALEATE

In this study, the polarographic behaviour and the optimum polarograph ic conditions for the determination of fluvoxamine using DC, DP and SI AP techniques are described based on the reduction on the DME. The exp eriments were conducted in the aqueous supporting electrolyte containi ng 0.2 M KCI, 20 % ethanol (v/v) and 0.2 M buffer solution. Single wav es were obtained at various pH values. The limiting currents were decr eased and E(1/2) values were linearly shifted to more negative potenti als with an increase of pH. The system was irreversible at both the ac idic and the basic medium and was controlled by adsorption at pH 4.2 a nd by diffusion at pH 8.03. The variation of the limiting current agai nst temperature was found to be 1.1 mu A/degrees C. Good calibration r elations were obtained for DC (direct current), DP (differential pulse ) and SIAP (superimposed increasing amplitude pulse) techniques. The d etermination of fluvoxamine in a pharmaceutical preparation, Faverin(R ) Tablets containing 50 mg of fluvoxamine, were tested. The results we re compared to those of UV-spectrophotometric method. In the analysis of a single 50 mp tablet, the relative standard deviation (S-rel) are found to be between +/-0.5 and +/-1.0 for the techniques employed for filtered and unfiltered solutions. The polarographic techniques used f or the determination of fluvoxamine seem to be accurate, rapid and pra ctical. Therefore, the suggested method may be promising in the routin e analysis.