LEUKEMIC OPHTHALMOPATHY - A REPORT OF 21 PEDIATRIC CASES

A multicentric retrospective study on leukemic ophthalmopathy (LO) is reported. It includes 21 patients, 16 males and 5 females, with acute leukemia (AL) observed in 10 SIOP centers. LO developed in three patie nts at the time of diagnosis of AL; five patients were in first comple te remission (three off therapy); four patients were in second or thir d remission; and nine were in combined relapse. Most frequent symptoms were blurred vision, photophobia, and ocular pain. Two patients with acute nonlymphoblastic leukemia died before treatment; another underwe nt bone marrow transplantation; one patient with B-cell acute lymphobl astic leukemia (B-ALL) treated with chemotherapy and radiotherapy died 4 months after LO; the remaining 17 children were treated according t o different schedules with (10) or without (7) radiotherapy on the aff ected eye. Twelve patients achieved ocular remission and four of these had a second ocular relapse. Complete remission after LO treatment la sting for more than 3, 7, 24, 29 months was observed in four patients. The authors conclude that cure is possible in patients who had LO in first complete remission treated with chemotherapy and radiotherapy at high dose on the affected eye. (C) 1994 Wiley-Liss, Inc.