PROGNOSIS OF PATIENTS WITH GASTRIC-CANCER AND PYLORIC-STENOSIS - HISTOLOGICAL DIFFERENTIATION

The clinicopathology of gastric cancer with pyloric stenosis was exami ned with special reference to histological differentiation. One hundre d sixteen patients treated in Department of Surgery II, Kyushu Univers ity Hospital, were classified into differentiated (DT: n = 47) and und ifferentiated types (UT: n = 69). The UT group was significantly young er than the DT group (P < 0.05). There were no differences in the inci dence of serosal invasion, liver metastasis, lymph node metastasis, an d the clinical stage between the groups. The incidence of peritoneal d issemination of the UT group was 41% (28/69), a value significantly hi gher than the 23% (11/47) for the DT group (P < 0.05). The 5-year surv ival rates of the DT and UT groups were 27% and 16%, respectively, wit h survival time for the UT group being significantly less than that of the DT group (P < 0.05). In patients with pyloric stenosis and an und ifferentiated adenocarcinoma with the risk of peritoneal dissemination , intensive adjuvant chemotherapy seems essential to improve the progn osis. (C) 1994 Wiley-Liss, Inc.