Since our first clinically successful TIPSS procedure in 1988 numerous
steps to improve the safety and methodology have helped to increase t
he technical and clinical success while the rate of complications coul
d be significantly reduced. In our series of more than 200 patients th
e technical success rate is more than 95 % and the early clinical succ
ess rate (< 30 days after TIPSS) 89 %, respectively. Early shunt occlu
sion was found in 1.5 % of our patients. 3 months after TIPSS, however
, transjugular portography reveals significant shunt stenosis in 46 %
needing either shunt re-dilatation or additional stent placement. This
relatively high rate of re-intervention is being significantly reduce
d during the further follow-up with a frequency of 17 % at a 6 month i
nterval and 6 % at a 12 month interval, respectively. The need for rei
ntervention is strongly associated with liver function and the patient
s' coagulation status: Child's A patients needed re-intervention subst
antially more often than those in stage B or C at each given follow-up
interval. The decreasing need for re-intervention over time appears t
o be associated with the formation of an endothelial cell layer on the
surface of the shunt tract.