This study examined (a) the prevalence and course of anxiety before th
e lst 6 infusions of cancer chemotherapy and (b) the contribution of t
rait anxiety, side effect expectations, and prior occurrence of posttr
eatment side effects to anxiety before infusions. Fifty-three women re
ceiving adjuvant chemotherapy for breast cancer participated. Anxiety
was most prevalent and intense before the 1st infusion. Trait anxiety
predicted anxiety before both the lst and subsequent infusions. Prior
occurrence of posttreatment nervousness also predicted anxiety before
subsequent infusions, even after accounting for trait anxiety and othe
r posttreatment side effects. Results are discussed in terms of the ro
le that anxiety proneness, response expectancy, and classical conditio
ning may play in the development of anxiety before repeated chemothera
py infusions.