AN AUTOPSY CASE OF LIGHT-CHAIN DEPOSITION DISEASE

This report describes a case of light chain deposition disease (LCDD) with unusual findings of fibrillar structures in the deposits and mark ed calcification in several organs. A forty-year-old man was initially diagnosed with LCDD in 1987, and died of sepsis three and one-half-ye ars later. Histological examination of autopsy specimens demonstrated eosinophilic amorphous materials, which differed from amyloid, in vess el walls or around parenchymal cells in almost every organ examined. U ltrastructurally, in addition to granular deposits, fibrillar structur es were also seen in the deposits. Marked calcification was present in the myocardium, skeletal muscles, adrenal glands and arteries.