IS HYPERINSULINEMIA A CENTRAL CHARACTERISTIC OF A CHRONIC CARDIOVASCULAR RISK FACTOR CLUSTERING SYNDROME - MIXED FINDINGS IN ASIAN INDIAN, CREOLE AND CHINESE MAURITIANS
Pz. Zimmet et al., IS HYPERINSULINEMIA A CENTRAL CHARACTERISTIC OF A CHRONIC CARDIOVASCULAR RISK FACTOR CLUSTERING SYNDROME - MIXED FINDINGS IN ASIAN INDIAN, CREOLE AND CHINESE MAURITIANS, Diabetic medicine, 11(4), 1994, pp. 388-396
Citations number
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Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
The aim of the study was to investigate whether the constellation of c
ardiovascular disease risk factors, described as Insulin Resistance Sy
ndrome, exists in the multi-ethnic population of Mauritius, and to ass
ess whether hyperinsulinaemia is the key feature of this syndrome. A s
ample of 5080 Mauritian subjects (aged 25-74 years) was examined in a
noncommunicable diseases survey in 1987. Survey procedure included an
oral glucose tolerance test, and anthropometric, blood pressure, plasm
a lipids and serum insulin measurements. Abnormal glucose tolerance (d
iabetes and impaired glucose tolerance), general obesity, upper-body o
besity, hypertension, low HDL-cholesterol, and hypertriglyceridaemia w
ere defined as risk factor conditions. Mean values for a series of ris
k factor variables were compared between reference subjects (no risk f
actors) and those with a risk factor condition (either one condition o
nly, or in combination with one or more others). Prevalence estimates
for each risk factor condition in combination with three or more other
conditions were three to four times greater than expected by chance,
and levels of risk factors for subjects with more than one risk factor
condition were further away from the reference levels than for those
with just one condition. Fasting and 2-h serum insulin levels were ele
vated for each condition when in combination with others, or to a less
er extent when isolated. However, this was not the case for isolated h
ypertension where insulin levels were not elevated. When adjusted for
age, sex, and body mass index, insulin levels were only significantly
elevated in subjects with upper-body obesity if in association with ge
neral obesity. A clustering of cardiovascular risk factors was therefo
re found in Mauritius. However, insulin levels although high for most
conditions were not high in hypertension.