SELECTIVE INABILITY OF LPS-ACTIVATED B-LYMPHOCYTES TO PRODUCE ANTIBODIES AGAINST AUTOLOGOUS AND ALLOGENEIC MHC CLASS-I ANTIGENS

Lipopolysaccharide (LPS)-activated B lymphocytes have been found to pr oduce autoantibodies of a variety of specificities. We found that LPS- induced autoantibodies did not include antibodies against self H-2 cla ss I antigens, suggesting a selective tolerance induction against some , but not other, autoantigens. However, LPS-activated B lymphocytes no t only failed to produce antibodies against autologous H-2 class I ant igens, but also against allogeneic H-2 class I antigens, suggesting a selective regulation of B cells to synthesize antibodies directed agai nst autologous and allogeneic major histocompatibility complex antigen s. (C) 1994 Academic Press, Inc.