Ma. Taylor et al., COMBINED-MODALITY TREATMENT USING BID RADIATION FOR LOCALLY ADVANCED NONSMALL CELL LUNG-CARCINOMA, Cancer, 73(10), 1994, pp. 2599-2606
Background. From February 1988 to August 1991, 82 patients were treate
d on a Phase II trial of split-course multimodality treatment for loca
lly advanced, non-small cell lung cancer (NSCLC). Methods. Treatment c
onsisted of twice-daily radiation (150 cGy/fraction) delivered with co
ncomitant infusional cisplatin, etoposide, and fluorouracil for 1 week
every third week. Patients were classified before initial treatment a
s either potentially resectable (eligible for surgery [ES]) or ineligi
ble for surgery (IES). The ES group consisted of 38 Stage IIIA and 7 S
tage IIIB patients. The IES group had 5 patients staged as IIIA and 32
staged as IIIB. Most patients were staged clinically. ES patients rec
eived three cycles of treatment (39 Gy) before resection. IES patients
received four cycles (60 Gy) delivered with curative intent. Results.
Thirty-nine of 45 ES patients underwent resection. The pathologic res
ponse rate was 27%. Three-year actuarial local control was 86% for 41
evaluable ES patients. Three-year actuarial survival for the whole ES
group was 39%, with a median follow-up for living patients of 32 month
s. The IES group faired less well, with an 18% 3-year actuarial surviv
al. Treatment was well tolerated with a median weight loss of one-half
pound, mild or moderate pneumonitis in 5%, mild esophagitis in 15%, a
nd severe nausea and/or vomiting in 10% of patients. Treatment-related
mortality was 5%. Conclusions. Patients treated with conventional rad
iation alone for Stage III NSCLC are rarely cured. This well tolerated
Phase II study demonstrated encouraging results for such patients. Bo
th local control and survival appeared promising, especially in patien
ts rendered resectable after combined-modality treatment.