CYTOGENETIC OBSERVATIONS FOLLOWING THALLIUM POISONING

Authors
HANTSON P DESOIR R LEONARD ED CRUTZENFAYT MC LEONARD A MAHIEU P
Citation
P. Hantson et al., CYTOGENETIC OBSERVATIONS FOLLOWING THALLIUM POISONING, Journal of toxicology and environmental health, 50(2), 1997, pp. 97-100
Citations number
11
Categorie Soggetti
Toxicology,"Environmental Sciences","Public, Environmental & Occupation Heath
Journal title
Journal of toxicology and environmental health → ACNP
ISSN journal
00984108
Volume
50
Issue
2
Year of publication
1997
Pages
97 - 100
Database
ISI
SICI code
0098-4108(1997)50:2<97:COFTP>2.0.ZU;2-S
Abstract
Observations have been performed on peripheral blood lymphocytes from a patient having ingested 200 mg thallium sulfate, in order to evaluat e the ability of the compound to produce cytogenetic damage in vivo in humans. Our results demonstrate that neither the yield of structural chromosome aberrations nor sister chromatid exchanges were significant ly modified The drastic increase of binucleated cells with micronuclei indicates that thallium sulfate has in common with many metallic comp ounds the ability to interfere with chromosome distribution.