INDOLOCARBAZOLES .4. SYNTHETIC STUDIES TOWARDS STAUROSPORINE AND TJIPANAZOLES - REACTIONS OF INDOLOCARBAZOLE WITH GLYCALS

In an attempt to construct the unique N,N'-bidentate glycosyl linkage found in the Staurosporine 1 class of natural products, the first exam ple of an acid catalyzed 2,6-condensation of an activated pyran with i ndolocarbazole 4 is reported. In pursuit of the real system, a variety of glycals were reacted with indolocarbazole 4. Formation of novel un expected products (B/C) with 13-connections along with the expected pr oduct (A) and its' synthetic transformation to a potentially useful in termediate 24 are detailed.