PH DEPENDENT C6 AND C8 C-13 CHEMICAL-SHIFT ASSIGNMENT IN N-ACETYL NEURAMINIC ACID

Authors
GERVAY J BATTA G
Citation
J. Gervay et G. Batta, PH DEPENDENT C6 AND C8 C-13 CHEMICAL-SHIFT ASSIGNMENT IN N-ACETYL NEURAMINIC ACID, Tetrahedron letters, 35(19), 1994, pp. 3009-3012
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
19
Year of publication
1994
Pages
3009 - 3012
Database
ISI
SICI code
0040-4039(1994)35:19<3009:PDCACC>2.0.ZU;2-P
Abstract
Heteronuclear correlation NMR spectroscopy was employed in the unambig ous carbon chemical shift assignment of N-acetyl neuraminic acid at pH 1.0 and 7.0. Our results show that at pH 1.0 the C6 resonance is slig htly downfield from that of C8 and at pH 7.0 the C6 and C8 chemical sh ifts are transposed. These experiments firmly establish carbon chemica l shift assignments in N-acetyl neuraminic acid for the first time.