A NOVEL PRODUCT FROM BECKMANN REARRANGEMENT OF ERYTHROMYCIN-A 9(E)OXIME

Authors
YANG BWV GOLDSMITH M RIZZI JP
Citation
Bwv. Yang et al., A NOVEL PRODUCT FROM BECKMANN REARRANGEMENT OF ERYTHROMYCIN-A 9(E)OXIME, Tetrahedron letters, 35(19), 1994, pp. 3025-3028
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
19
Year of publication
1994
Pages
3025 - 3028
Database
ISI
SICI code
0040-4039(1994)35:19<3025:ANPFBR>2.0.ZU;2-A
Abstract
Beckmann rearrangement of erythromycin A 9(E)-oxime with toluenesulfon yl chloride in ethyl ether at -45 degrees C generates 9,11-imino ether IV which leads to azithromycin. The 9,11-imino ether can also be read ily obtained from isomerization of its isomer 6,9-imino ether III.