EFFECTS OF EPIDERMAL GROWTH-FACTOR DOSAGE FORMS ON DERMAL WOUND STRENGTH IN MICE

The effect of topically administered epidermal growth factor (EGF) dos age forms was investigated on skin wound healing in mice. Two EGF dosa ge forms were prepared containing 100 ng mL-1 EGF. The solution dosage form was prepared in 0.9% w/v NaCl. A bioadhesive gel form was prepar ed in 0.2%. Carbopol 940 polymer. The two dosage forms were applied on the skin incision wounds of mice at the rate of 5 muL twice a day for 7 and 15 days. The wound tear strength was tested for skin wound heal ing at the 7th and 15th days of treatment and compared with controls. The results indicate that the wound tear strength of mice were signifi cantly higher at the 15th day of treatment in the gel-treated group co mpared with the solution-treated mice and controls (P<0.001).