Ma. Arnott et al., SELECTIVE EFFECTS OF PENTAMIDINE ON CYTOSOLIC AND GRANULE-ASSOCIATED ENZYME-RELEASE FROM ZYMOSAN-ACTIVATED HUMAN NEUTROPHILIC GRANULOCYTES, Journal of Pharmacy and Pharmacology, 46(5), 1994, pp. 394-396
Therapeutic concentrations (0.3-1.5 mg L-1) of pentamidine isethionate
, normally obtainable in-vivo after parenteral administration of the d
rug, did not affect the in-vitro activity of the enzymes lysozyme, bet
a-glucuronidase or myeloperoxidase released from zymosan-activated hum
an neutrophilic granulocytes. At concentrations of 0.7, 1.1 and 1.5 mg
L-1, activity of cytosolic enzymes lactate dehydrogenase and glucose-
6-phosphate dehydrogenase were reduced relative to untreated cells (P<
0.001 and P<0.01, respectively), but not in a dose-dependent fashion.
Cell viability, as determined by dye-exclusion remained unaffected.