EVIDENCE FOR A DOPAMINERGIC INVOLVEMENT IN THE RENAL ACTION OF CENTRALLY ADMINISTERED JA116A, A NOVEL COMPOUND WITH POSSIBLE DOPAMINERGIC ACTIVITY, IN RATS

Intracerebroventricular (i.c.v.) administration of JA116a, induces an increase in urinary volume and sodium excretion in conscious male hydr ated rats. The involvement of brain dopaminergic neurons in the JA116a renal action was investigated. Diuretic and natriuretic action of JA1 16a was blocked by haloperidol pretreatment. The renal effect was prev ented by selective dopaminergic neuron, denervation by i.c.v. administ ration of 6-hydroxydopamine in combination with desmethylimipramine. O ur results suggest that JA116a acts centrally, at least in part, via a n interaction with endogenous dopamine neurons.