Stretching of the internal carotid artery during percutaneous translum
inal angioplasty (PTA) may be associated with transient neck, facial o
r cranial pain. We report a series of 53 cases who received PTA. Cervi
cal pain occurred in 51% of patients, with a radiation to face and sca
lp in 33%. Analysis focused on: (a) description of pain intensity, qua
lity, timing and location; (b) investigation about the role of individ
ual and technical parameters that could influence the relative risk of
pain onset during PTA; (c) comparison with other available data on pa
in syndromes related to the carotid artery. Intimal flapping on post-a
ngioplasty angiograms, bradycardia during the procedure and previous h
istory of AMI were associated with a higher risk of painful angioplast
y. PTA may also serve as a tool to investigate carotid pain and may ad
d further knowledge to the evidence available about the role of the ca
rotid wall in the pathogenesis of facial and cranial pain.