SPECIFIC MICROBIAL SPECIEs have been closely associated with periodont
itis. Through longitudinal studies, some of.these microbial species ha
ve been implicated in the etiology of progressive periodontal disease.
Although putative periodontal pathogens are often isolated from indiv
iduals with severe periodontitis, they also frequently inhabit the sub
gingival environment and are not always associated with advanced disea
se. In this respect, it is becoming increasingly apparent that there i
s no single etiology of the various periodontal diseases. Destructive
periodontal diseases are the result of environmental, host, and bacter
ial factors. Microorganisms, however, are essential components of any
model for progressive periodontitis. This paper selectively reviews ba
cteria as risk markers for periodontitis. Attention focuses on bacteri
a in conjunction with behavioral patterns (oral hygiene habits and smo
king) and host response (gingival crevicular fluid substances) as risk
markers for periodontitis. Prospective studies implicating specific b
acteria in progressive periodontitis are addressed and a bacterial ris
k assessment model for progressive periodontitis is discussed with res
pect to the interplay between bacterial, environmental, and host marke
rs.