THE VALUE OF PHOSPHOHEXOSE ACTIVITY MEASU REMENT IN URINE COMPARED WITH CYTOLOGICAL EXAMINATION - DIAGNOSIS AND FOLLOW-UP OF PATIENTS WITH TRANSITIONAL-CELL CARCINOMA

The importance of phosphohexose (PHI) activity in the urine of patient s with carcinoma of the urinary bladder is examined on the basis of en zyme-histochemical studies in tumor cell homogenisates after transuret hral resection for transitional cell carcinoma. The results gave rise to the question of whether the enzyme-histochemical activity patterns were reflected in the urine in the form of photometrically measurable activity, and thus whether the PHI activity can be used in screening a s a marker to complement the standard urine cytological procedure. The sensitivity of PHI measurement was determiend at 89%. The measurement of PHI in the urine of patients with an ileum neobladder or of patien ts with urinary tract infections does not provide any useful informati on.