IMIPENEM AND MEROPENEM INDUCED RESISTANCE TO BETA-LACTAM ANTIBIOTICS IN PSEUDOMONAS-AERUGINOSA

Authors
GIACOMETTI A SIQUINI FM CIRIONI O PETRONI S SCALISE G
Citation
A. Giacometti et al., IMIPENEM AND MEROPENEM INDUCED RESISTANCE TO BETA-LACTAM ANTIBIOTICS IN PSEUDOMONAS-AERUGINOSA, European journal of clinical microbiology & infectious diseases, 13(4), 1994, pp. 315-318
Citations number
14
Categorie Soggetti
Immunology,Microbiology
Journal title
European journal of clinical microbiology & infectious diseases → ACNP
ISSN journal
09349723
Volume
13
Issue
4
Year of publication
1994
Pages
315 - 318
Database
ISI
SICI code
0934-9723(1994)13:4<315:IAMIRT>2.0.ZU;2-5
Abstract
The ability of imipenem and meropenem in subinhibitory concentrations to influence the results of disk diffusion susceptibility tests was as sessed. Selection of stably derepressed mutants resistant to beta-lact am antibiotics other than carbapenems was also investigated. Beta-lact ams were shown to be subject to carbapenem-mediated antagonism in the disk diffusion test. On the other hand in vitro selection of stably de repressed mutants resistant to other beta-lactams could not be demonst rated.