Gh. Jackson et al., RAPID ONSET OF CHRONIC GRANULOCYTIC-LEUKEMIA AFTER TREATMENT FOR HODGKINS-DISEASE, British Journal of Haematology, 87(1), 1994, pp. 193-195
A 17-year-old white female presented with stage IVB Hodgkin's disease.
After chemotherapy and radiotherapy she achieved a complete clinical
remission and underwent an autologous bone marrow transplant (ABMT). 2
2 months later she developed chronic granulocytic leukaemia (CGL). Pol
ymerase chain reaction (PCR) analysis of bone marrow harvested at the
time of ABMT did not show any evidence of the bcr-abl sequence that wa
s detectable at the diagnosis of CGL. This case provides further infor
mation on the kinetics of the development of CGL and adds to the small
pool of data on CGL developing after treatment for Hodgkin's disease.