SCEDOSPORIUM-INFLATUM INFECTION IN IMMUNOCOMPROMISED HEMATOLOGICAL PATIENTS

We report four cases of Scedosporium inflatum (S. inflatum) infection in severely immunocompromised haematological patients. Six well-docume nted cases of S. inflatum disseminated infection in haematological pat ients have been reported: four in Australia and two in Spain. Their cl inical and pathological characteristics are heterogenous, particularly in the Australian cases. However, the clinical and pathological profi le emerging from our and other Spanish cases is homogenous and very si milar to the clinico-pathological spectrum of other disseminated mycos es, including Aspergillus and S. apiospermum. The optimal treatment of S. inflatum infection is unknown and the outcome in haematological pa tients is very poor. Eight patients died despite systemic antifungal t reatment.