AMNESIC SYNDROME AFTER THEOPHYLLINE ASSOCIATED SEIZURES - IATROGENIC BRAIN INJURY

Authors
ORIORDAN JI HUTCHINSON J FITZGERALD MX HUTCHINSON M
Citation
Ji. Oriordan et al., AMNESIC SYNDROME AFTER THEOPHYLLINE ASSOCIATED SEIZURES - IATROGENIC BRAIN INJURY, Journal of Neurology, Neurosurgery and Psychiatry, 57(5), 1994, pp. 643-645
Citations number
15
Categorie Soggetti
Psychiatry,Neurosciences,"Clinical Neurology
Journal title
Journal of Neurology, Neurosurgery and Psychiatry → ACNP
ISSN journal
00223050
Volume
57
Issue
5
Year of publication
1994
Pages
643 - 645
Database
ISI
SICI code
0022-3050(1994)57:5<643:ASATAS>2.0.ZU;2-L
Abstract
Two patients developed a disabling amnesic syndrome after seizures ass ociated with oral theophylline treatment. Such seizures are more likel y in the elderly, in the presence of pre-existing neurological disease , and when theophylline is given with certain antibiotics and cimetidi ne. The mechanism of neuronal injury may be by the excessive release o f endogenous excitotoxic glutamate.