D. Tumelty et al., IMMOBILIZED, ACTIVATED PEPTIDES AS REAGENTS FOR CYCLIC AND DERIVATIZED PEPTIDE LIBRARIES, Journal of the Chemical Society, Chemical Communications, (9), 1994, pp. 1067-1068
Cyclic peptides have been synthesised from an immobilised; activated i
ntermediate, where activation of the immobilised peptide is carried ou
t with the N-alpha-protecting group intact, its subsequent removal lea
ding to cyclisation.