DIVERSE MOLECULAR-INTERACTIONS OF THE HNRNP K-PROTEIN

The hnRNP K protein is a versatile molecule that interacts with RNA, D NA, the proto-oncoprotein VaV, Src-like tyrosine and inducible serine/ threonine kinases, the transcription factor TBP and a number of zinc-f inger transcriptional repressors. The interaction of K protein with so me of its protein partners is modulated by nucleic acids and K protein can alter the in vivo and in vitro rate of transcription. K protein c an simultaneously engage several proteins and may facilitate molecular cross-talk. Taken together these diverse interactions suggest that K protein may act as a nucleic acid-regulated docking platform. (C) 1997 Federation of European Biochemical Societies.