M. Cantore et al., INTRAARTERIAL HEPATIC CARBOPLATIN-BASED CHEMOTHERAPY FOR OCULAR MELANOMA METASTATIC TO THE LIVER - REPORT OF A PHASE-II STUDY, Tumori, 80(1), 1994, pp. 37-39
Aims and Background: ocular melanoma tends to metastasize to the liver
, sparing for a long time the rest of the organism. Therefore, a regio
nal treatment is especially indicated. Methods: eight patients with oc
ular melanoma metastatic to the liver were treated with intra-arterial
hepatic carboplatin-based chemotherapy at the dose of 300 mg/m2 once
every two weeks at an out-patient clinic. All the patients were submit
ted to laparotomy with surgical implantation of an arterial port devic
e through the gastroduodenal artery. Results: the overall response rat
e was 38% with a median survival time of 15 months. The regimen was we
ll tolerated and the principle toxicity was myelosuppression; any inst
ance of hepatic and/or cholangitic damage was reported. Conclusions: C
arboplatin seems suitable for intra-arterial hepatic chemotherapy and
active in ocular melanoma metastic to the liver.