SPECTROPHOTOMETRIC INVESTIGATION OF THE CELIPROLOL-HYDROCHLORIDE ION-PAIR

Celiprolol-hydrochloride has been determined using benzylorange and fo rming ion-pair. The absorbance of yellow coloured ion-pair is measured at 401 nm. Unknown concentrations of celiprolol-hydrochloride is calc ulated by using the calibration graph of the following calibration equ ation: y = 0.1602 x + 0.0214 The conditional stability constant of the ion-pair at the optimum pH 6.2 and ionic strength 0.05 is found to be 5.63. The method is successfully applied to the determination of celi prolol-hydrochloride in pharmaceutical preparations.