BIOCOMPATIBILITY AND OSTEOCONDUCTIVITY OF THE PYROST BONE SUBSTITUTES

The purpose of this study was to re-evaluate the bone regeneration pow er and the in vitro biocompatibility of the Pyrost bone substitute. Tw enty-four adult New Zealand White rabbits were used. Bony defect over both iliac crest and mid-diaphyseal portion of the ulna bone were crea ted. Appropriate sized-block of Pyrost bone substitute were implanted. Four of the animals were killed at each postoperative month to evalua te its bone regeneration power by histologic study. The Pyrost bones w ere co-cultured with osteoblasts to evaluate its biocompatibility. The results showed that Pyrost bone substitute was quite stable and incor porated well with active bone regeneration. The Pyrost heal better at the iliac crest than at the ulnar defect. The Pyrost was compatible to the osteoblasts. Osteoblasts had successfully seeded and mitotically expanded on the porous surface of the Pyrost bone graft. The result sh owed that Pyrost bone obviously exerts an intense stimulus on osteo-re generation in the presence of osteoblasts. We consider Pyrost to be an alternate to the conventional preserved allografts that is occasional ly necessary.