ENZYMATIC RESOLUTION OF 4-METHYLTETRAHYDRO-2H-PYRAN-2-ONE, 4-PHENYLTETRAHYDRO-2H-PYRAN-2-ONE AND 6-PHENYLTETRAHYDRO-2H-PYRAN-2-ONE USING ESTERASES

Authors
IZUMI T TAMURA F AKUTSU M
Citation
T. Izumi et al., ENZYMATIC RESOLUTION OF 4-METHYLTETRAHYDRO-2H-PYRAN-2-ONE, 4-PHENYLTETRAHYDRO-2H-PYRAN-2-ONE AND 6-PHENYLTETRAHYDRO-2H-PYRAN-2-ONE USING ESTERASES, Journal of heterocyclic chemistry, 31(2), 1994, pp. 441-445
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
31
Issue
2
Year of publication
1994
Pages
441 - 445
Database
ISI
SICI code
0022-152X(1994)31:2<441:ERO44>2.0.ZU;2-1
Abstract
Enantioselective hydrolysis of racemic tetrahydro-2H-pyran-2-ones (del ta-valerolactones) using esterase resulted in the formation of optical ly active (R)-4-methyl-, (R)-4-phenyl- or (R)-6-phenyltetrahydro-2H-py ran-2-ones and the corresponding (S)-delta-hydroxypentanoic acid deriv atives.