We describe a 35-year-old man with a primary cystic mediastinal hemang
iopericytoma who presented with the complaint of progressive dysphagia
for 6 months. The computed tomography and magnetic resonance imaging
findings revealed that a well-defined, fluid-filled mass (measuring ap
proximately 10x10 cm) was located posterior to the heart and inferior
to the carina of the bronchus. Tumor puncture showed translucent yello
w fluid with normal concentrations of carcinoembryonic antigen, squamo
us cell carcinoma-related antigen, and carbohydrate antigen 19-9 and a
high concentration of carbohydrate antigen 125. After removal of the
tumor, microscopic examination revealed a malignant hemangiopericytoma
. To our knowledge, this is the first case of a primary mediastinal he
mangiopericytoma with cystic formation. Moreover, we showed the specif
ic biochemical findings of the cystic fluid that were useful for diffe
rentiation from other cystic mediastinal tumors.