An autopsy case of an 83-year-old Japanese woman with pancreatic cance
r with significantly elevated serum alpha-fetoprotein levels is report
ed. The pancreatic tumor was a mucinous cystadenocarcinoma with multip
le metastasis to the liver. The immunohistochemistry for alpha-fetopro
tein revealed positive reactivity in the cytoplasm of cancer cells in
the primary and liver metastatic lesions. The current case is the firs
t reported in which mucinous cystadenocarcinoma of the pancreas produc
ed alpha-fetoprotein.