FETAL ENCEPHALOPATHY WITH CEREBRAL CALCIFICATIONS - A CASE-REPORT

The authors report a case of a newborn with severe encephalopathy and cerebral calcifications. The newborn was admitted to Neonatal Intensiv e Care Unit in Chieti at 2 days of age suffering from continuous gener alized seizures. He was the child of healthy first-degree cousins. Cer ebral ultrasonography showed bilateral ventricular dilatation and an i ntrathalamic hyperechoic image. Computed tomography and magnetic reson ance imaging showed ventricular and corpus callosus hypoplasia, pachyg yria, widespread delayed myelination areas, and basal nuclei and periv entricular calcifications. All serum and urine analyses showed normal results. In particular, all demyelinizing metabolic diseases were excl uded. Based upon these findings, we speculate that this infant may be suffering from fetal encephalopathy with cerebral calcifications.